PTH-Related Peptide (PTHrP) in Hypercalcemia
نویسندگان
چکیده
منابع مشابه
PTH-related peptide (PTHrP) in hypercalcemia.
It is now 20 years since the tumor-associated factor parathyroid hormone-related peptide was identified. Since then, there have been significant changes in the understanding of the hypercalcemic syndromes associated with malignancy and with the role of this peptide in normal physiology as well as this specialized pathologic setting. Parathyroid hormone-related peptide has become a useful diagno...
متن کاملParathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the Type I PTH/PTHrP receptor
A number of studies suggest a role for PTHrP and the classical PTH/PTHrP receptor (type I) in one of the first differentiation processes in mouse embryogenesis, i.e. the formation of parietal endoderm (PE). We previously reported that although in type I receptor (-/-) embryos PE formation seemed normal, the embryos were smaller from at least day 9.5 p.c. and 60% had died before day 12.5 p.c. He...
متن کاملSubsternal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level
BACKGROUND Parathyroid adenoma is the most common cause of primary hyperparathyroidism. Preoperative serum calcium and intact-parathyroid hormone levels are the most useful diagnostic parameters that allow differentiating primary hyperparathyroidism from non-parathyroid-dependent hypercalcemia. Parathyroidectomy is the definitive treatment for primary hyperparathyroidism. Approximately 5% of pa...
متن کاملPTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development.
Endochondral bone development is a fascinating story of proliferation, maturation, and death. An understanding of this process at the molecular level is emerging. In particular, significant advances have been made in understanding the role of parathyroid-hormone-related peptide (PTHrP), parathyroid hormone (PTH), and the PTH/PTHrP receptor in endochondral bone development. Mutations of the PTH/...
متن کاملprehypertrophic cells, stimulates expression of parathyroid hormone (PTH)-related peptide (PTHrP) which negatively regulates terminal chondrocyte differentiation through the PTH/PTHrP receptor (PPR). However, the roles of PTHrP and Ihh in regulating earlier steps in chondrocyte
Developing murine growth plates comprise at least three morphologically distinct groups of chondrocytes (see Fig. 3C): round periarticular chondrocytes, flat columnar chondrocytes and hypertrophic chondrocytes. Periarticular chondrocytes proliferate and differentiate into columnar chondrocytes that proliferate further and form orderly columns. Unlike the round periarticular chondrocytes, the fl...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2008
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007090981